The world’s first “human challenge” to deliberately contract COVID-19 has been found to be safe

2022-08-06 0 By

Early in the outbreak, some researchers called for a quick way to determine whether a COVID-19 vaccine was effective, by actively infecting vaccinated volunteers and pushing forward with further research on the novel coronavirus, according to British media reports.The world’s first novel coronavirus test of active infection is safe for healthy young volunteers, the team responsible for carrying out the world’s first human challenge said on Tuesday.The year-long trial was conducted by Irish pharmaceutical company Open Orphan in collaboration with Imperial College London, the UK government’s vaccine Working Group and clinical company hVIVO.These data support the safety of the model and lay the foundation for future novel Coronavirus studies, the team added.In this landmark human Challenge study, 36 volunteers aged 18 to 29 who had never been infected with novel Coronavirus were infected with a small dose of novel Coronavirus via nasal drops.It found that 18 volunteers became infected, and 16 of them subsequently developed mild to moderate flu-like symptoms, including nasal congestion or runny nose, sneezing and sore throat.Some people also experience headaches, muscle/joint pain, tiredness and fever.But none have developed serious symptoms.In addition, 13 of the infected volunteers temporarily lost their sense of smell, but all but three of the participants had regained their sense of smell within 90 days.All three volunteers showed improvement after three months.The researchers found that symptoms appeared very quickly after infection, taking only two days on average.Specifically, the virus first appears in the larynx, and then the viral load peaks around the fifth day.This is also when the most obvious symptoms usually appear.At this stage, the viral load in the nasal cavity is significantly higher than in the throat.The average duration of virus survival in most people’s nasal passages is 6.5 days.Until now, experts, including those from the World Health Organization (WHO), have generally agreed that it takes five to six days for a person to develop symptoms of novel coronavirus infection.The team said they are now looking at other parts of the trial, including investigating why 16 of the 34 participants did not become infected after being exposed to the virus;Some people can detect the virus in their nasal passages, but do not test positive for nucleic acid.